Proposed Use of Deoxycholic Acid (DCA) and Ursodeoxycholic Acid (UDCA) in a Treatment Regimen for Barrett’s Esophagus

Citation: Stamp D. (2016). Proposed Use of Deoxycholic Acid (DCA) and Ursodeoxycholic Acid (UDCA) in a Treatment Regimen for Barrett’s Esophagus. M J Canc. 1(2): 007. INTRODUCTION Huo et al [1] first placed 250 uM of the hydrophobic bile acid (DCA) into the esophagus of patients with Barrett’s esophagus (BE) and left it there for 5 min. The DCA was dissolved in alcohol. Subsequent examination of the biopsies taken from the esophagus showed that the DNA was damaged and the nuclear factor NF-kB was activated. Additionally, many other pre-cancerous lesions were activated. Similar treatment with the hydrophilic bile acid (UDCA) was ineffective, suggesting that UDCA could be an anti-carcinogen.